Software Development

Modeling epilepsy using human induced pluripotent stem cells

• Technological advances in hardware to measure brain activity at the cellular level and software driven by complex algorithms have facilitated rapid progress towards objective diagnosis and treatment of neurological disorders.

• Electrophysiology can now be analyzed in the laboratory at an unprecedented cellular level using high-density microelectrode arrays (MEAs) and machine learning classifiers to objectively quantify neuronal function and response to therapeutic intervention. 

• Modern tissue engineering strategies, including the re-engineering of human induced pluripotent stem cells, allow the use of the patient’s own cells “on a chip,” thereby replicating the brain chemistry of the neurological disorder in a laboratory environment and facilitating rapid development of precision-guided therapeutics.

In Silico Software Modeling